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Moving Beyond Reactive Retention to Sustained Inclusion

A Strategic Collaboration Proposal for AIR Site Alliance and PatientX

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Moving Beyond Reactive Retention
Shifting from Patient Diversity to Sustained Inclusion
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Moving Beyond Reactive Retention
Shifting from Patient Diversity to Sustained Inclusion
Moving Beyond Reactive Retention to Sustained Inclusion1 / 12
The Macro Problem
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The $8 Million-a-Day Choke Point
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Linear pipeline graphic with severe drop-off between recruitment and completion
Linear pipeline graphic with severe drop-off between recruitment and completion
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    30–40% baseline participant dropout rate
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    80% of trials delayed due to enrollment/retention failures
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    $1M–$8M daily cost of a delayed Phase III trial
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The Compounding Micro-Economics of Attrition
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    $6,500 average cost to recruit one participant
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    $19,500 to replace a dropped participant
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    38% of dropouts cite trial journey as 'stressful'
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Strategic Alignment
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Validating the Alliance’s Retention by Design
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    AIR’s 'Four Bs' community model
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    Decentralized trials & mobile units
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    PatientX quantifies trust at the clinic
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    Measures if tools reduce burden or add fatigue
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Journey-Mapped Telemetry
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Timeline with four phases: Screening, Clinic Visits, Between-Visit, Support Network
Timeline with four phases: Screening, Clinic Visits, Between-Visit, Support Network
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    Zone 1: Screening & Consent → Comprehension Metric
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    Zone 2: Clinic Visits → Burden Metric
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    Zone 3: Between-Visit → Communication Metric
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    Zone 4: Support Network → Empathy Metric
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Unmasking Structural and Cultural Friction
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    70% of participants live >2 hours from sites
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    Mistrust barrier: third-party data builds safety
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    Literacy barrier: real-time comprehension tracking
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    Logistical friction disproportionately affects diverse cohorts
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    Patients voice concerns anonymously via PatientX
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    Prevents accidental non-compliance in low-SES groups
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Benchmarking Site Performance
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Mock dashboard showing site scorecards with patient experience ratings
Mock dashboard showing site scorecards with patient experience ratings
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    11% of sites enroll zero participants
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    Clone best practices from top-performing sites
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    Use validated reviews to boost community enrollment
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“
Why wait for the next study to fix what’s broken today?
PatientX
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Early Adopter Alliance Pilot
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    3–5 AIR Alliance Oncology/Ophthalmology sites
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    Multi-language surveys (Spanish, Arabic, Urdu, Hindi)
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    Link high PX Scores to low attrition and faster timelines
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Behind Every Data Point is a Real Human Being
Questions & discussion, contact email or link...

Approve 3-site pilot framework • Finalize protocol parameters with PatientX • Launch pilot to protect Roche’s timelines

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